The village was founded in the early 18th dynasty and occupied for roughly four hundred years, through to the end of the 20th dynasty, when work on the royal tombs stopped and the community dispersed.
It housed something like sixty to seventy families at its height. The workforce was a single crew divided into a right side and a left side, each under its own foreman and its own scribe — terminology borrowed from the crew of a ship.
A Ptolemaic temple to Hathor and Maat stands at the northern end of the site. It was later taken over as a Coptic monastery, and that is where the modern name comes from: Deir el-Medina means the monastery of the town.
Sennedjem's tomb was opened intact in 1886, its painted chamber sealed since the 19th dynasty. An Italian mission under Ernesto Schiaparelli found a second undisturbed burial in 1906 — Kha, an overseer of works, and his wife Merit, with their furniture, linen and tools still in place. That household is in Turin now.
Bernard Bruyère then dug here for the French institute in Cairo from 1922, clearing the houses, the cemeteries and the great pit north of the village — a shaft sunk as a well, abandoned dry, then used as a dump. It held thousands of inscribed flakes.