The site was a place of Christian pilgrimage from the fourth century. The fortified monastery was built under the emperor Justinian in the sixth century, and the original church, its doors and its apse mosaic survive.
It was named for Saint Catherine of Alexandria, whose relics tradition says were brought here.
The Codex Sinaiticus, one of the oldest substantially complete manuscripts of the Christian Bible, was found here in the nineteenth century; most of it is now in the British Library.
The library's fame rests on more than one famous book. It holds thousands of manuscripts in Greek, Arabic, Syriac, Georgian and Slavonic, and modern multispectral imaging has been recovering erased texts beneath later writing — palimpsests — including works that survive nowhere else.
The mosque inside the walls tells the story of the monastery's long accommodation with Muslim rulers: converted from a guesthouse in the Fatimid period, it served the Bedouin who worked for the monastery. The Jabaliya tribe of the surrounding valleys still trace their descent, by tradition, to the garrison families Justinian settled here to protect it.